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Youth Mental Health

Mental health issues among young people are increasing. Preventative measures are crucial, but not all youth benefit from them. This can be due to various reasons, such as challenging living conditions, financial hardships or biological factors that play a significant role in disorders such as depression, and anxiety, as well as suicidal thoughts. The Perron Institute Youth Mental Health team is focused on researching these biological changes and how they influence the development of poor mental health, the choice of treatment, and the outcomes of those treatments.

Research Focus

Led by Professor Jennifer Rodger, Professor Anthony Akkari and Professor Sean Hood, the Perron Institute’s Youth Mental Health team has four research priorities:

  1. Partnering with young people
    We work with young people who have lived experience of mental health challenges to understand their experiences of seeking care, considering treatment options and living with depression and anxiety. Their perspectives help ensure that our research is relevant, respectful and responsive to community needs.
  2. Partnering with medical professionals
    We collaborate with GPs, psychiatrists and other healthcare professionals to identify gaps in existing care pathways and understand the practical challenges involved in delivering personalised mental healthcare.
  3. Advancing personalised mental healthcare
    We are investigating how biological information, including Pharmacogenomic (PGx) testing, could support more individualised treatment decisions. Our research examines not only whether these approaches may improve care, but also how they can be implemented safely, equitably and effectively across Western Australia.
  4. Expanding treatment options
    We investigate the safety, acceptability and potential benefits of different treatment approaches for young people, including non-invasive brain stimulation interventions such as Transcranial Magnetic Stimulation (TMS).

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Current Youth Mental Health Studies

StudyRole in the programStatus
GENE-YD
Tests whether PGx-guided antidepressant prescribing is feasible and may improve treatment outcomes for young people
Completed; findings emerging
PGx-ADAPT
Develops and evaluates a practical model for implementing PGx-guided prescribing across metropolitan, rural and remote WA
Current
PRIME Care
Engages young people in co-designing research about the acceptability, communication and implementation of PGx-guided treatment
Current; Actively Recruiting
PharmacoMap
Examines Psychedelic-Assisted Psychotherapy through PGx Screening
Current
Preparing for Precision
Engages with Medical Students about their Perceptions, Ethical Reasoning, and Communication Strategies in Personalised Youth Mental Health Treatment using PGx-guided prescribing
Current
Towards Personalised Depression Treatment
Examines rTMS Efficacy and Genetic Biomarkers in Treatment-Resistant Patients
Current
TMS MRI Study
Examines the safety and efficacy of rTMS for the treatment of youth depression
Current; Actively Recruiting
TMS EEG Study
Establishes effects of various rTMS protocols within and between individuals
Current; Actively Recruiting
Suicidal Ideation Treatment Study
Advances TMS with PGx and other genetic screening techniques in the treatment of youth with depression and suicide ideation
Coming in 2027
Epilepsy Study
Investigates the safety, efficacy, and feasibility of rTMS to treat depression in patients with epilepsy
Current

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