Stroke research sub-category

The neuroprotective peptide poly-arginine-12 (R12) reduces cell surface levels of NMDA NR2B receptor subunit in cortical neurons; investigation into the involvement of endocytic mechanisms. MacDougall G, Anderton RS, Edwards AB, Knuckey NW, Meloni BP 2017 Journal of Molecular Neuroscience 61:235-246

Peptide pharmacological approaches to treating traumatic brain injury: a case for arginine-rich peptides. Chiu LS, Anderton RS, Knuckey NW, Meloni BP. 2017 Molecular Neurobiology. DOI 10.1007/s12035-016-0287-3

Assessment of the neuroprotective effects of arginine-rich protamine peptides, poly-arginine peptides (R12-cylic, R22) and arginine-tryptophan containing peptides following in vitro excitotoxicity and/or permanent middle cerebral artery occlusion in rats Meloni BP, Milani D, Cross JL, Clark VW, Edwards AB, Anderton RS, Blacker DJ, Knuckey NW 2017 Neuromolecular Medicine 19: 271-285

Modification to the Rice-Vannucci perinatal hypoxic-ischaemic encephalopathy model in the P7 rat improves the reliability of cerebral infarct development after 48 hours. Edwards AB, Feindel KW, Cross JL, Anderton RS, Clark VW, Knuckey NW, Meloni BP 2017 Journal of Neuroscience Methods 288:62-71

Pathophysiology and Neuroprotective Strategies in Hypoxic-Ischemic. Brain Injury and Stroke Meloni BP. 2017 Editorial, Brain Sciences 7, 110; doi:10.3390/brainsci7080110

Assessment of neuroprotective peptides poly-arginine R18, COG1410, and APP96-110 experimental traumatic brain injury and in vitro neuronal excitotoxicity. Chiu LS, Anderton RS, Clark VW, Edwards AB, Knuckey NW, Meloni BP. (2017). Translational Neuroscience. DOI:

Delayed 2h post-stroke administration of R18 and NA-1 (TAT-NR2B9c) peptides after permanent and/or transient middle cerebral artery occlusion in the rat. Milani, D., Cross, J.L., Anderton, R.S., Blacker, D.J., Knuckey, N.W., Meloni, B.P. (2017). Brain Research Bulletin 28, 135:62-68. DOI: 10.1016/j.brainresbull.2017.09.012

The R18 Polyarginine Peptide Is More Effective Than the TAT-NR2B9c (NA-1) Peptide When Administered 60 Minutes after Permanent Middle Cerebral Artery Occlusion in the Rat. Milani D, Knuckey NW, Anderton RS, Cross JL, Meloni BP. 2016. Stroke Res Treat, 2016, 2372710. doi: 10.1155/2016/2372710.

Bird, S.M., Sohrabi, H.R., Sutton, T.A., Weinborn, M., Rainey-Smith, S.R., Brown, B., Patterson, L., Taddei, K., Gupta, V., Carruthers, M., Lenzo, N., Knuckey, N., Bucks, R.S., Verdile, G., Martins, R.N. (2016) ‘Cerebral amyloid-β accumulation and deposition following traumatic brain injury-A narrative review and meta-analysis of animal studies’, Neuroscience and Biobehavioral Reviews, 64, 1, pp. 215-228. Detail

Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke model. Milani D, Clark VW, Cross JL, Anderton RS, Knuckey NW, Meloni BP. 2016. BMC Neurosci, 17(1), 19. doi: 10.1186/s12868-016-0253-z.